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KMID : 1007520110200010251
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Food Science and Biotechnology
2011 Volume.20 No. 1 p.251 ~ p.254
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Anti-diabetic Effect of Watermelon (Citrullus vulgaris Schrad) on Streptozotocin-induced Diabetic Mice
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Ahn Ji-Yun
Choi Won-Hee
Kim Sun-A
Ha Tae-Youl
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Abstract
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The anti-diabetic potential of watermelon (Citrullus vulgaris Schrad) was evaluated in vivo. ICR mice were fed experimental diet containing none, 10% watermelon flesh powder (WM-P) or 1% watermelon rind ethanol extract (WM-E). At the end of 4 weeks, mice were administrated with streptozotocin (40 mg/kg, i.p.) for 5 consecutive days to induce diabetes. Supplementation with WM-E significantly decreased blood glucose level and increased serum insulin levels. Feeding of WM-P also induced moderate changes but those were not statistically significant. Immunohistochemical analysis showed watermelon effectively protected pancreatic cells death. These results suggest that watermelon has a beneficial effect on diabetes.
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KEYWORD
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watermelon (Citrullus vulgaris Schrad), antidiabetic, streptozotocin, insulin
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